Major acting coup for E! late night hostess Chelsea Handler: The spifire blonde — recently romantically-linked to rapper 50 Cent — will play Reese Witherspoon’s best friend in the upcoming comedy This Means War.

The project from 20th Century Pictures features Inception hunk Tom Hardy and Chris Pine of the summer hit Star Trek.

Production begins later this month.

Chelsea’s previous acting credits include bit parts in little known titles like Cattle Call and Steam.

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