Mr. Hopper died from complications of prostate cancer. His death was first reported by Reuters.
Hopper had recently been suffering from prostate cancer and going through a difficult divorce from his wife Victoria.
Hopper is best known for starring in the 1969 classic “Easy Rider.”
Mr. Hopper, who said he stopped drinking and using drugs in the mid-1980s, followed that change with a tireless phase of his career in which he claimed to have turned down no parts.
His credits include at least six films released in 2008 and at least 25 over the past 10 years.