It’s all over for British screen stars Jude Law and Sienna Miller.

The exes — who famously split when Jude was caught diddling his children’s nanny behind Sienna’s back five years ago only to reunite in 2009 — have once again gone their separate ways, celebrity informants tell PEOPLE.

Jude and Sienna called it quits for good several weeks ago, Law’s rep confirms.

“It is mutual and amicable and they are still friends,” says a friend of the actors. “It was an entirely and end-of-the relationship decision. It had run its course.”

The former couple last made headlines when Jude’s ex-wife, Sadie Frost, publicly slammed Sienna for giving her young daughter a haircut without her permission.

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